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Freelance translator and/or interpreter, Verified site user
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English to Italian: Dysfunctional BLK in common variable immunodeficiency perturbs B-cell proliferation and ability to elicit antigen-specific CD4+ T-cell help General field: Science Detailed field: Biology (-tech,-chem,micro-)
Source text - English Common Variable Immunodeficiency (CVID) is the most prevalent primary antibody deficiency, and characterized by defective generation of high-affinity antibodies. Patients have therefore increased risk to recurrent infections of the respiratory and intestinal tract. Development of high-affinity antigen-specific antibodies involves two key actions of B-cell receptors (BCR): transmembrane signaling through BCR-complexes to induce B-cell differentiation and proliferation, and BCR-mediated antigen internalization for class-II MHC-mediated presentation to acquire antigen-specific CD4+ T-cell help.We identified a variant (L3P) in the B-lymphoid tyrosine kinase (BLK) gene of 2 related CVID-patients, which was absent in healthy relatives. BLK belongs to the Src-kinases family and involved in BCR-signaling. Here, we sought to clarify BLK function in healthy human B-cells and its association to CVID.
Translation - Italian L'immunodeficienza comune variabile (CVID), il deficit anticorpale primario a più alta prevalenza, è caratterizzata da un difetto nella generazione di anticorpi ad alta affinità. I pazienti affetti da questa malattia presentano quindi un aumentato rischio di infezioni ricorrenti del tratto respiratorio e intestinale. Lo sviluppo di anticorpi antigene-specifici ad alta affinità richiede l'esecuzione di due azioni fondamentali da parte dei recettori dei linfociti B (BCR). In primo luogo, la trasduzione transmembrana di segnali attraverso i complessi BCR induce la differenziazione e proliferazione dei linfociti B; in un secondo momento, l'internalizzazione dell'antigene mediata dai BCR permette la sua presentazione tramite il complesso maggiore di immunoistocompatibilità (MHC) di tipo II e l'attivazione di linfociti T CD4+ con funzioni di aiuto. Analizzando il gene BLK (B-lymphoid tyrosine kinase) di due pazienti affetti da CVID appartenenti alla stessa famiglia, abbiamo identificato una variante (L3P) assente in consanguinei sani. La proteina BLK appartiene alla famiglia delle chinasi Src ed è coinvolta nella trasduzione di segnali da parte del BCR. In questo articolo, vogliamo delucidare la funzione di BLK in linfociti B umani sani e la sua associazione con l'immunodeficienza comune variabile.
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Experience
Years of experience: 2. Registered at ProZ.com: May 2006.
(Complete Italian and English CVs available upon request. Please get in touch through Proz mail)
Name: Serena Arduini
Mother tongue: Italian
Language pairs: EN > IT
Education:
1. Bachelor's degree in Biotechnologies, completed in Italy;
2. Master's degree in Medical and Pharmaceutical Biotechnologies, conferred summa cum laude in Italy after defense of a thesis in English;
3. PhD in Translational Immunology awarded by Trinity College Dublin. During this research project, I dissected the role of innate T cells in Common Variable Deficiency, a rare primary antibody deficiency with frequent autoimmune complications;
4. Graduate Certificate in Clinical Research, completed at University College Dublin (GPA 3.92 out of 4.20).
Professional experiences:
• currently working in the clinical research industry, as a Clinical Development Scientist with a focus on gene therapy for rare paediatric diseases. Previous clinical site monitoring experience;
• extensive knowledge of laboratory and clinical environments, in Italy, Denmark, Ireland and the UK;
• freelance translator and proofreader of medical and scientific documents, including patient information leaflets and consent forms for clinical trials, original research articles, data sheets for laboratory reagents and diagnostic kits, instruction manuals for medical devices.
Hands-on laboratory experience, a knowledge of clinical and research environments and an extensive background in the life sciences make me the perfect translator for documents requiring a thorough understanding of technical subjects and terminology and a highly accurate rendition. I pride myself on the quality and accuracy of my work, ensuring you will receive a relevant and perfectly polished translation of your source text.
Please contact me through Proz for assignments, or to request a CV.
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