GBK glossarySearch the glossaries created from glossary-building KudoZ (GBK) questions. | To see the desired glossary, please select the language and then the field of expertise. |
Home - English
- Medical: Pharmaceuticals
- Search
- Term
- Additional fields of expertise
- Definition(s)
- a measure of how much of an administered drug is absorbed into the bloodstream, actually reaching the intended site of action in the body. For example, medicine is absorbed from the GI tract, travels through the bloodstream, and reaches the organ tissues, where it works to fight infection, prevent rejection, etc. USC Kidney Transplant Program
- Example sentence(s)
- Differences in bioavailability among formulations of a given drug can have clinical significance; thus, knowing whether drug formulations are equivalent is essential.
- Merck & Co., Inc.
by - The term “relative bioavailability” refers to a comparison of two or more dosage forms in terms of their relative rate and extent of absorption. If an intravenous injection is employed as the reference dose, one can determine the absolute bioavailability of the test dosage form. - Informa plc
by - Drug candidates can be tested for their desired therapeutic activity, but it is not yet possible to predict whether or not a compound will have sufficient bioavailability to be useful and practical. - US National Institutes of Health
by Compare [close] - German
- Medical: Pharmaceuticals
- Search
- Term
- Additional fields of expertise
- Definition(s)
- Was versteht man unter Bioverfügbarkeit?
Unter Bioverfügbarkeit versteht man die Menge eines Nährstoffs, die tatsächlich aus dem Lebensmittel in den Körper aufgenommen und für diesen verfügbar gemacht wird. Diese Menge entspricht nicht unbedingt der Menge, die über die Nahrung zugeführt wird. Dabei geben die Mechanismen der Absorption (Nährstoffaufnahme aus dem Darm in den Körper) Auskunft über das Verhältnis der mit der Nahrung zugeführten Menge zu der vom Körper aufgenommenen Menge. Bärenapotheke - by Bensaid
- Example sentence(s)
- Die Bioverfügbarkeit ist eine pharmakologische Messgröße für den Anteil eines Stoffes, der unverändert im systemischen Kreislauf (speziell: im Blutkreislauf) zur Verfügung steht. Sie gibt an, wie schnell und in welchem Umfang der Stoff (meistens Arzneistoff) resorbiert wird und am Wirkort zur Verfügung steht. - Wikipedia
by Bensaid - Related KudoZ question
Compare [close] - Russian
- Medical: Pharmaceuticals
- Search
- Term
- Additional fields of expertise
- Definition(s)
- Биодоступность (обозначают буквой F) в фармакокинетике и фармакологии — величина введенной дозы неизмененного лекарства, которая достигла системного кровообращения ru.wikipedia.org - by boostrer
- Example sentence(s)
- Для определения относительной биодоступности могут использоваться данные об уровне содержания лекарственного вещества в крови или же его экскреции с мочой.
- Книга
by boostrer - Относительная биодоступность при приеме таблеток по сравнению с раствором - 94%, абсолютная биодоступность при приеме внутрь - 70% - Рисперидон
by boostrer - Related KudoZ question
Compare [close] - Portuguese
- Medical: Pharmaceuticals
- Search
- Term
- Additional fields of expertise
- Definition(s)
- A biodisponibilidade é um termo farmacocinético que descreve a velocidade e o grau com que uma substância activa ou a sua forma molecular terapeuticamente activa é absorvida a partir de um medicamento e se torna disponível no local de acção. A avaliação da biodisponibilidade é realizada com base em parâmetros farmacocinéticos calculados a partir dos perfis de concentração plasmática do fármaco ao longo do tempo.
infarmed - by Ligia Dias Costa
- Example sentence(s)
- A biodisponibilidade dos alimentos diz respeito à quantidade de nutrientes absorvidas e utilizadas pelo organismo. Isso porque nem todos os nutrientes - www.rgnutri.com.br/sqv/saude/bda.php
by Ligia Dias Costa - Biodisponibilidade é uma medida da extensão de uma droga terapeuticamente ativa que atinge a circulação sistêmica e está disponível no local de ação - wikipedia
by Ligia Dias Costa - Related KudoZ question
Compare [close] - Croatian
- Medical: Pharmaceuticals
- Search
- Term
- Additional fields of expertise
- Definition(s)
- Bioraspoloživost jest brzina i stupanj apsorpcije ljekovite tvari iz farmaceutskog oblika definirana krivuljom odnosa koncentracije i vremena u sistemskoj cirkulaciji ili izlučivanjem u urinu. Ministarstvo zdravstva - by eleonora_r
- Example sentence(s)
- Međutim, bioraspoloživost lijeka iz tablete vrlo je kompleksan pojam i rezultati ovog testa samo su određeni pokazatelj, a stvarna bioraspoloživost utvrđuje se određivanjem razine lijeka u krvi ispitanika nakon primjene lijeka u kliničkom pokusu. - Belupo
by eleonora_r - Bioraspoloživost lijekova odraz je prvenstveno fizikalno-kemijskih parametara uključenih u procese apsorpcije i eliminacije. - Hrvatska znanstvena bibliografija
by eleonora_r - Related KudoZ question
Compare [close] - Japanese
- Medical: Pharmaceuticals
- Search
- Term
- Additional fields of expertise
- Definition(s)
- Example sentence(s)
- 腎不全患者に対してβ遮断薬プロプラノロールを経口投与すると、薬物血中濃度(AUC)が健常者の7〜8倍に増大する事が1970年代に報告された。その後の研究によって腎疾患時の薬物血中濃度の上昇は経口投与時のバイオアベイラビリティの上昇(肝臓における初回通過効果の低下)に起因する事が明らかにされているが、その詳細なメカニズムは不明であった。本研究では、腎機能低下時における肝代謝型薬剤のバイオアベイラビリティ変動機構を解明するため、数種類の腎障害モデルラットを用いて検討した。その結果、シスプラチン誘発腎障害モデルでは「小腸における薬物吸収速度の増加によって、肝初回通過代謝に飽和性がある薬剤のバイオアベイラビリティが上昇する。」との知見を得た。しかし、尿管結紮腎障害モデルの場合は、「小腸吸収速度の上昇は認められず、肝サイトゾル画分のNADPH生成速度の低下に起因する肝クリアランスの低下によって、バイオアベイラビリティが上昇する。」事が示唆された。 - 腎障害時における肝代謝型薬�
by Yoshiko La Salvia - [目的]レボスルピリドドロップの人体バイオアベイラビリティを検討した。[方法]健常男性被験者20例は,無作為クロスオーバー法で,レボスルピリドドロップあるいはスルピリド錠の単回経口投与群に分けた。レボスルピリドの血中濃度は,RP‐HPLCで測定し,薬物速度論パラメータと相対バイオアベイラビリティは3p97プログラムで算出した。[結果]試験製剤と基準製剤のc_(max)は,392.98±158.62μg mL‾(−1)と415.02の±137.80μg mL‾(−1),t_(max)は3.43±1.2と3.23+0.66h,AUC_(0〜36)は,3602.99±761.15μg L‾(−1)hと3693.40±870.50μg L‾(−1)h,AUC_(0〜∞)は,3837.11±787.25と3958.60±881.07)μg L‾(−1)hで,試験製剤の相対バイオアベイラビリティは,98.7±12.0%であった。 - 中国文献ディレクトリシステ�
by Yoshiko La Salvia - Related KudoZ question
- Compare this term in: Serbian, Albanian, Arabic, Bulgarian, Catalan, Czech, Chinese, Danish, Dutch, Greek, Spanish, Finnish, French, Hebrew, Hindi, Hungarian, Italian, Latvian, Lithuanian, Macedonian, Norwegian, Polish, Romanian, Slovak, Slovenian, Swedish, Thai, Turkish, Ukrainian, Vietnamese
| | The glossary compiled from Glossary-building KudoZ is made available openly under the Creative Commons "By" license (v3.0). By submitting this form, you agree to make your contribution available to others under the terms of that license. ![Creative Commons License](http://i.creativecommons.org/l/by/3.0/88x31.png) | | | | X Sign in to your ProZ.com account... | | | | | | |