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- Gene silencing: A mechanism by which cells shut down large sections of chromosomal DNA. Gene silencing is done by incorporating the DNA to be silenced into a form of DNA called heterochromatin that is already silent.
The process of gene silencing is important for the differentiation of many different types of cells. MedicineNet, Inc.
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- Evidence is emerging that geminiviruses and plant pararetroviruses can interact with the gene silencing system either from introduced DNA constructs or during viral pathogenesis. Some observations suggest there are complex relationships between DNA viral activity, transcriptional and post-transcriptional gene silencing mechanisms. - biotech-info.net by
- The biggest challenges in the field at the moment are understanding two things: how does DNA methylation participate in gene silencing (and that includes what molecules target the DNA methylation to these promoter regions), and why is the cancer cell doing this? - The Thomson Corporation by
- In 2005, Pikaard and his collaborators published research showing that the major function of Pol IV is to generate siRNAs, thereby singling out this RNA polymerase as a potential player in gene silencing. - ScienceDaily LLC by
Compare [close] - Swedish
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- När en gen tystas ned, genom t.ex. RNA-interferens, talar man på svenska om genavstängning (gene silencing). Hos växter som används som livsmedel kan man blockera eller reducera bildningen av oönskade ämnen, till exempel sådana som kan framkalla allergi. Djurmodeller av vissa sjukdomar, till exempel högt blodkolesterolvärde, kan påverkas gynnsamt genom genavstängning. I en klinisk prövning använder man RNA-interferens för att blockera en gen som är verksam vid en näthinnesjukdom. Nationalencyklopedin: Nobelpriset 2006 - by egj_translation
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Compare [close] - Arabic
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- عبارة عن عملية تقوم الخلايا من خلالها بإغلاق أو تعطيل (تصميت) قطاعات كبيرة من الحامض النووي للكروموسومات. بالإضافة إلى أهمية هذه العملية في تنوع الخلايا التي يتم تصنيعها فإنها أيضاً تعتبر حصناً مناعياً ضد الفيروسات وغيرها من العناصر النووية الضارة. Own research - by Fahd Hassanein
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Compare [close] Compare [close] - Catalan
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- Procés durant el qual un gen no s'expressa. Termcat - by Marià Pitarque
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- D'altra banda, ARN petits, de tant sols uns 21-22 nucleòtids de llargada, també poden regular l'expressió de gens. Alguns d'aquests ARN actuen sobre regions del trànscrit madur d'un gen abans de la subseqüent síntesi de proteïna, aconseguint silenciar el gen. Mecanisme conegut com silenciament genètic postranscripcional o PTGS. - UPF by Marià Pitarque
- El treball dels científics de l’ICO Girona no acaba aquí. Mitjançant l’ús de fàrmacs experimentals i tècniques de silenciament genètic han demostrat que la inhibició de l’autofàgia fa que les cèl·lules resistents es tornin sensibles al trastuzumab de nou. - ICO by Marià Pitarque
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