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- Biology (-tech,-chem,micro-)
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- Gene silencing: A mechanism by which cells shut down large sections of chromosomal DNA. Gene silencing is done by incorporating the DNA to be silenced into a form of DNA called heterochromatin that is already silent.
The process of gene silencing is important for the differentiation of many different types of cells. MedicineNet, Inc.
- Example sentence(s)
- Evidence is emerging that geminiviruses and plant pararetroviruses can interact with the gene silencing system either from introduced DNA constructs or during viral pathogenesis. Some observations suggest there are complex relationships between DNA viral activity, transcriptional and post-transcriptional gene silencing mechanisms. - biotech-info.net
by - The biggest challenges in the field at the moment are understanding two things: how does DNA methylation participate in gene silencing (and that includes what molecules target the DNA methylation to these promoter regions), and why is the cancer cell doing this? - The Thomson Corporation
by - In 2005, Pikaard and his collaborators published research showing that the major function of Pol IV is to generate siRNAs, thereby singling out this RNA polymerase as a potential player in gene silencing. - ScienceDaily LLC
by Compare [close] - Croatian
- Biology (-tech,-chem,micro-)
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- Razvitak tehnika poput
interferencije RNK koja omoguæava
stišavanje gena koji
potièu bolesti i starenje, pokazala
je da se medicina transformirala
u informacijsku
tehnologiju, istièe šezdesetogodišnji
Kurzweil. Vjesnik - by PeregrineFalcon
- Example sentence(s)
- Craig Mello
Izvor: Wikipedija
Craig Cameron Mello (rođen 18. listopada 1960.) je američki biolog koji je 2006.g. dobio Nobelovu nagradu za fiziologiju ili medicinu zajedno sa Andrew Fireom za njihovo otkriće RNK interferencije (engl. RNA interference - RNAi) - stišavanja gena (engl. gene silencing) dvostrukom RNK. - Wikipedija
by PeregrineFalcon - Ključne reči: mijelodisplastični sindrom, hipermetilacija DNA, stišavanje gena, inhibitori DNA metiltransferaze
Key words: Myelodysplastic syndrome. DNA hypermethylation, Gene silencing - Medicina danas
by PeregrineFalcon - Tim postupcima se neznatno mijenja genom (ukupna količina gena) ili se postojeći gen "pojačava" ili "stišava" da bi se dobilo željeno svojstvo unutar vrste. - Coolinarika
by PeregrineFalcon - Related KudoZ question
Compare [close] Compare [close] - Serbian
- Biology (-tech,-chem,micro-)
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- Utišavanje gena se koristi pri isključivanju gena mehanizmima različitim od genetske modifikacije, a koji su povezani sa epigenetikom, odnosno regulacijom gena kroz delovanje faktora okoline. Gen koji bi u normalnim okolnostima bio aktiviran je u utišavanju gena nužno isključen, a glavni uzrok tome je RNK interferencija. Own research - by Milan Djukić
- Example sentence(s)
- Epigenetske modifikacije dovode do promena genske ekspresije bez uticaja na sekvencu DNK. DNK metilacija je oblik epigenetske modifikacije, gde hipermetilacija CpG ostrvaca promotora dovodi do transkripcionog utišavanja gena i maligne transformacije. - Društvo genetičara Srbije
by Milan Djukić - Bazična nauka je i ranije bila upoznata sa procesom post-transkripcionog utišavanja gena. Ipak, iako su mnogi enzimi bili poznati, tek otkrivanje RNAi je omogućilo da se stvori potpuna slika o preciznosti i mogućnostima regulisanja ekspresije pojedinih gena. Koliko je RNAi odgovorna za epigenetske procese je i dalje u centru pažnje mnogih naučnih grupa. No, ono što je bilo najinteresantnije kada je fenomen RNAi razjašnjen je njen potencijal za genetska istraživanja. Utišavanje gena je veoma elegantan i precizan način da se izučava njegova funkcija bez previše neželjenih efekata. Takodje, moguće je i regulisati specifičan gen u specifično vreme i u odredjenim ćelijama. - Stetoskop.info
by Milan Djukić - "Utišavanjem gena mogu da se analiziraju ponašanje miša i fiziološke promene do kojih dolazi, a tako može da se zaključi kakva je normalna funkcija tog gena", kaže Goldberg. - Politika
by Milan Djukić - Related KudoZ question
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