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English
- Medical (general)
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    - Term
      - chimeric antigen receptor (CAR) T-cell therapy
    - Additional fields of expertise
    - Definition(s)
      - Chimeric antigen receptor (CAR) T-cell therapy is a promising new way to get immune cells called T cells (a type of white blood cell) to fight cancer by changing them in the lab so they can find and destroy cancer cells. CAR T-cell therapies are sometimes talked about as a type of gene or cell therapy, or immune effect cell therapy. American Cancer Association
    - Example sentence(s)
      - Chimeric antigen receptor (CAR) T-cell therapy has had great success in treating patients with relapsed or refractory B-cell malignancies, with CD19-targeting therapies now approved in many countries. However, a subset of patients fail to respond or relapse after CD19 CAR T-cell therapy, in part due to antigen loss, which has prompted the search for alternative antigen targets. - Research Square by
      - Chimeric antigen receptor (CAR) T-cell therapy represents a major advancement in personalized cancer treatment. In this strategy, a patient's own T cells are genetically engineered to express a synthetic receptor that binds a tumor antigen. CAR T cells are then expanded for clinical use and infused back into the patient's body to attack and destroy chemotherapy-resistant cancer. - PubMed by
      - In the past 5 years, knowledge of immunology in thoracic cancers has greatly improved. The results observed with immunotherapy are encouraging. For example, in patients with stage 4 non–small cell lung cancer, 5-year survival was previously 2%. That survival rate has now increased to approximately 20% with the use of checkpoint blockade immunotherapy. Similarly, early data from our trial combining chimeric antigen receptor (CAR) T-cell therapy and checkpoint blockade in mesothelioma were promising. - Hematology & Oncology by

Spanish
- Medical (general)
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    - Term
      - Terapia de linfocitos T-CAR
    - Additional fields of expertise
    - Definition(s)
      - La terapia de linfocitos T-CAR o terapia de linfocitos T con receptor quimérico para el antígeno es un tipo de tratamiento para el cáncer que se vale de estos linfocitos para combatir infecciones del sistema inmunitario. Cosnautas - by María Eugenia Bartolomé
    - Example sentence(s)
      - "En la mayoría de los casos, los linfocitos T CAR son células autólogas obtenidas del propio paciente, activadas ex vivo, modificadas con un vector viral que codifica las secuencias CAR y expandidas aún más antes de ser infundidas en el paciente, un proceso que puede durar de 10 a 15 días (excluyendo exámenes de calidad)." - Scielo by María Eugenia Bartolomé
      - "La estructura de un linfocito T CAR se compone de un dominio extracelular que reconoce y se une específicamente a un antígeno tumoral y un dominio intracitoplasmático que activa la respuesta de la célula T". - Rev. Colegio de Microb. Quim. by María Eugenia Bartolomé
      - Los linfocitos T-CAR se identifican mediante citometría de flujo en cuanto a su expresión de la proteína CAR, y por PCRc para detectar el transgén CAR. - Min. Transformación Ecológica de Espa� by María Eugenia Bartolomé
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