Early Treatment Diabetic Retinopathy Study (ETDRS)
ETDRS was a multicenter, randomized clinical trial designed to evaluate argon laser photocoagulation and aspirin treatment in the management of patients with nonproliferative or early proliferative diabetic retinopathy. A total of 3,711 patients were recruited to be followed for a minimum of 4 years to provide long-term information on the risks and benefits of the treatments under study.

The eligibility criteria for the ETDRS were designed to include a broad range of macular edema severity, from a few small hard exudates within a disc diameter of the fovea with normal visual acuity to extensive cystoid spaces with a visual acuity of 20/200. All study patients had one eye randomly assigned to immediate photocoagulation and the other eye to deferral of photocoagulation until high-risk proliferative retinopathy developed. During followup, additional photocoagulation was allowed for any degree of macular edema within the eligibility range, but additional photocoagulation was required only for edema involving or threatening the center of the macula. The term "clinically significant macular edema" was coined to designate this level of severity.


ETDRS was a multicenter, randomized clinical trial designed to evaluate argon
... The eligibility criteria for the ETDRS were designed to include a broad ...
http://www.clinicaltrials.gov/ct/show/NCT00000151 -; new link: http://www.clinicaltrials.gov/ct/show/NCT00000151?order=1
Early Treatment Diabetic Retinopathy Study (ETDRS ...
The International Council of Ophthalmology (ICO) works with ophthalmologic
societies, ophthalmologists and others to enhance ophthalmic education and the ...
http://www.icoph.org/ed/etdrs.html -
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