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se tituló como abogado (Corte Suprema de Chile, 1968)
diestro prolongada

Glossary entry

Spanish term or phrase:

doble marcación

English translation:

Dual-labelled or double-labelled

Added to glossary by Louise Etheridge
Jan 14, 2013 16:04
11 yrs ago
5 viewers *
Spanish term

doble marcación

Spanish to English Medical Medical (general) Clinical trial documentation
This appears in a clinical trial document in reference to pharmacokinetic studies on brexpiprazole , does it mean 'double blind'?

Many thanks

Louise
Proposed translations (English)
4 +1 Dual-labelled or double-labelled
References
finding only

Discussion

Louise Etheridge (asker) Jan 15, 2013:
Many thanks to everyone for your contributions to this. Yes, 'unlabelled' and 'dual-labelled' certainly seem to fit the context.
Filippe Vasconcellos de Freitas Guimarães Jan 15, 2013:
Yes! I think Biomed Sci has hit the nail on the head. Post it as a response, perhaps?
liz askew Jan 15, 2013:
Thank you Biomed Sci. I was very sceptical about "branded":) My findings showed "unlabelled" = no marcado. Cheers!
Biomed Sci Jan 15, 2013:
Or "dual-labeled" The metabolism and disposition of dual 14C-labeled peliglitazar...
Biomed Sci Jan 15, 2013:
Another e.g. The subjects initially received either a single oral or intravenous (i.v.) dose of 1 mg of [14C]tesaglitazar. After a washout period, they received 1 mg of nonlabeled tesaglitazar via the alternative administration route
Biomed Sci Jan 15, 2013:
e.g. Alosetron is extensively metabolized in humans. The biological activity of the metabolites is unknown. A mass balance study was performed utilizing an orally administered dose of unlabeled and 14C-labeled alosetron
Biomed Sci Jan 15, 2013:
Unlabelled and double labelled Perhaps it refers to unlabelled and carbon-14 double-labelled
brexpiprazole
liz askew Jan 15, 2013:
Hi
You need to ask the client about this one as I can find no information about the use of these phrases in relation to the drug in question.
Louise Etheridge (asker) Jan 14, 2013:
I've just had another thought on this. Could it be that 'no marcado' indeed means 'generic' and 'doble marcación' means double-brand/dual brand? Apparently it is quite common for meds to be marketed under two brands these days... Any thoughts? Many thanks
Louise Etheridge (asker) Jan 14, 2013:
Many thanks Taña. It's interesting that the article you posted mentions the word 'generic' as it had occured to me that that could be the context, 'generic' as in 'non-branded'. Well that gives me some more information to ponder...
Taña Dalglish Jan 14, 2013:
See: (not sure if this will shed any further light on the issue): http://www.proz.com/kudoz/english_to_spanish/medical:_health... (marcado/sin marcar)
Louise Etheridge (asker) Jan 14, 2013:
Here is the sentence in question:
"Los estudios de farmacocinética del brexpiprazol se realizaron usando brexpiprazol no marcado y 14Cbrexpiprazol con doble marcación...

I thought 'no marcado' could mean blind therefore 'doble marcación' double blind, but I really can't seem to find any information to corroborate this.

Many thanks, Louise
liz askew Jan 14, 2013:
Yes, kindly provide at least two sentences of Spanish context.
Filippe Vasconcellos de Freitas Guimarães Jan 14, 2013:
Agreed An accurate answer will be nearly impossible without additional context.
In a pharmacokinetic study this is probably "double staining" (an immunohistochemisry technique) but that's just a guess.
Yvette Neisser Moreno Jan 14, 2013:
Could you please provide more context, at least the whole sentence?

Proposed translations

+1
3 days 22 mins
Selected

Dual-labelled or double-labelled

See example sentences in discussion.
Peer comment(s):
agree Filippe Vasconcellos de Freitas Guimarães
10 hrs
Something went wrong...
4 KudoZ points awarded for this answer. Comment: "Many thanks for your help on this and thanks to everyone who contributed, Louise"

Reference comments

1 hr
Reference:

finding only

Flow cytometric identification of microorganisms by dual staining ...
cat.inist.fr/?aModele=afficheN&cpsidt... - Translate this page
by JS MILLER - 1990 - Cited by 37 - Related articles
Mots-clés anglais / English Keywords. Double labelling. ;. Identification. ;. Bacteria ... Mots-clés espagnols / Spanish Keywords. Marcación doble. ;. Identificación ...

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Note added at 1 hr (2013-01-14 17:31:44 GMT)
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label > marcación / marcador
www.proz.com/?sp=gloss/term&id=4802870
One translation of the English term label in Spanish is marcación / marcador. Glossary name: My Kudoz points. Source: ProZ.com user glossaries » sugrass ...

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Note added at 17 hrs (2013-01-15 09:16:45 GMT)
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https://docs.google.com/viewer?a=v&q=cache:5nvaQTx9800J:www....

see page 11

ligante no marcado
ligante radiomarcado
Ligand (biochemistry) - Wikipedia, the free encyclopedia
en.wikipedia.org/wiki/Ligand_(biochemistry)
Binding affinity is most commonly determined using a radiolabeled ligand, known as hot ligand. Homologous competitive binding experiments involve ...

[PDF]
radioligand binding assays - BHF Human Receptor Research Group
www-davenport.medschl.cam.ac.uk/documents/R20.PDFFile Format: PDF/Adobe Acrobat - Quick View
modified to provide a suitable site for radiolabelling. In both cases, it is not always predictable that the selectivity and specificity of an unlabelled ligand will be ...
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