I would rephrase this passage to the effect of "...syndromes characterized predominantly by hepatocellular dysfunction (chronic liver failure), bile duct obstruction (cholestasis) or portal hypertension..."

Classically, liver disease can be classified as necrotic (i.e., due to primary hepatocyte destruction) or obstructive/cholestatic (when hepatocyte injury is secondary; cholangiocytes, the cells of the biliary tree, are those primarily affected). The passage seems to describe an extension of this "textbook" classification.