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- Medical: Pharmaceuticals
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- a measure of how much of an administered drug is absorbed into the bloodstream, actually reaching the intended site of action in the body. For example, medicine is absorbed from the GI tract, travels through the bloodstream, and reaches the organ tissues, where it works to fight infection, prevent rejection, etc. USC Kidney Transplant Program
- Example sentence(s)
- Differences in bioavailability among formulations of a given drug can have clinical significance; thus, knowing whether drug formulations are equivalent is essential.
- Merck & Co., Inc.
by - The term “relative bioavailability” refers to a comparison of two or more dosage forms in terms of their relative rate and extent of absorption. If an intravenous injection is employed as the reference dose, one can determine the absolute bioavailability of the test dosage form. - Informa plc
by - Drug candidates can be tested for their desired therapeutic activity, but it is not yet possible to predict whether or not a compound will have sufficient bioavailability to be useful and practical. - US National Institutes of Health
by Compare [close] - Catalan
- Medical: Pharmaceuticals
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- Proporció de principi actiu d'un preparat farmacèutic que s'absorbeix i arriba a la circulació de tot l'organisme disponible per actuar.
Termcat, Centre de Terminologia - by CocoVilaseca
- Example sentence(s)
- Biodisponibilitat d’un medicament
Existeixen tres paràmetres per caracteritzar com un medicament subministrat està disponible en la zona d’acció. Aquests paràmetres son:
• tmax: Temps que passa des que el medicament és subministrat fins que la seva concentració disponible és màxima.
• Cmax: Concentració disponible màxima.
• AUC1: Quantitat total de medicament absorbit pel cos. - XTEC, Xarxa Telemàtica Educativa de Cat
by CocoVilaseca - Per tal que un ingredient bioactiu exerceixi una acció òptima, aquest ha de ser alliberat en el lloc d'actuació i en una concentració efectius durant el període desitjable; això és coneix com a biodisponibilitat. - Centre Tecnologic de Nutrició i Salut
by CocoVilaseca - L´administració de medicaments per via oral és la més fisiològica i la més recomanada quan el fàrmac té una bona biodisponibilitat i les condicions del malalt ho fan possible. - Institut Català de la Salut
by CocoVilaseca - Related KudoZ question
Compare [close] Compare [close] - Latvian
- Medical: Pharmaceuticals
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- bioloģiskā pieejamība;bioavailability;biopieejamība bio-availability Kopienas vērtējumprocedūra, Valsts va - by Inese Poga-Smith
- Example sentence(s)
- 107. Farmakokinētikas pētījumos veic attiecīgus bioloģiskās pieejamības pētījumus, lai noteiktu bioekvivalenci šādos gadījumos:
107.1. no jauna formulētās veterinārās zāles salīdzina ar jau esošām zālēm;
107.2. jaunu ievadīšanas ceļu vai paņēmienu salīdzina ar jau esošo.
5. Ja saskaņā ar šo noteikumu 23.punktu bioloģiskas izcelsmes veterinārās zāles, kas ir līdzīgas bioloģiskas izcelsmes atsauces veterinārajām zālēm, neatbilst ģenērisko zāļu definīcijā minētajiem nosacījumiem, iesniedzējs iesniedz informāciju saskaņā ar šo noteikumu 2. vai 3.pielikuma 1. un 2.nodaļu (farmaceitiskie, ķīmiskie un bioloģiskie dati). Iesniedzamo informāciju papildina ar datiem par veterināro zāļu bioekvivalenci un biopieejamību, kā arī sniedz papildu datus, īpaši par veterināro zāļu drošumu un iedarbīgumu. - Cabinet Regulations, Republic of Latvia
by Inese Poga-Smith - ... bioloģiskās pieejamības un bioekvivalences pētījumi jāplāno un jāveic saskaņā ar Labas klīniskās prakses prasībām. - Medikamentu informācijas centrs
by Inese Poga-Smith - English Translation: bioloģiskā pieejamība
Language Expression English Translation or Definition
Latvian bioloģiskā pieejamība bioavailability.
Refers to that proportion of a drug which reaches the systemic circulation unchanged after a particular route of administration When drugs are taken by mouth their bioavailability is determined by factors in the drug-which include the nature of the molecule, its stability, and the formulation administered-and in the patient-such as a reduced intestinal surface area as a result of coeliac disease or intestinal resection and whether or not the drug is taken with a meal. Source: European Union. (references) - Webster's Online dictionary
by Inese Poga-Smith - Related KudoZ question
Compare [close] - Slovenian
- Medical: Pharmaceuticals
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- biološka uporabnost, biološka razpoložljivost
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- Biološka razpoložljivost ali biološka uporabnost je farmakološko merilo deleža neke snovi, ki je v nespremenjeni obliki razpoložljiv v sistemskem krvnem obtoku. Običajno se izraz nanaša na količino resorbirane učinkovine, ki je dejansko na razpolago v tarčnem tkivu. Tako je biološka razpoložljivost ena izmed poglavitnih farmakokinetičnih lastnosti zdravila Wikipedia - by Tjasa Kuerpick
- Example sentence(s)
- BIOLOŠKA UPORABNOST je količina zdravila, ki pride v krvni obtok in prodre do tkiv in organov po vsem telesu. Izražena je v odstotkih dane količine zdravila. Pri injekciji zdravila v žilo je biološka uporabnost 100 %. Zdravila, ki jih použijemo, imajo precej nižji odstotek, saj se skozi prebavila vsrka le del zdravila - Celjske lekarne
by Tjasa Kuerpick - Obvezen je preskus zgornje in spodnje dovoljene meje vseh tistih pomožnih snovi, ki bi lahko vplivale na biološko uporabnost učinkovin, razen če je biološka uporabnost preverjena z drugimi ustreznimi preskusi. - Uradni list RS, št. 73/2000 z dne 19. 8
by Tjasa Kuerpick - Biološka uporabnost nam pove koliko (%) zdravila se bo absorbiralo v kri. Kakšen del zdravila, ki ga pojemo pride v kri. - Zdravstvena info
by Tjasa Kuerpick - Related KudoZ question
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