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- Gene silencing: A mechanism by which cells shut down large sections of chromosomal DNA. Gene silencing is done by incorporating the DNA to be silenced into a form of DNA called heterochromatin that is already silent.
The process of gene silencing is important for the differentiation of many different types of cells. MedicineNet, Inc.
- Example sentence(s)
- Evidence is emerging that geminiviruses and plant pararetroviruses can interact with the gene silencing system either from introduced DNA constructs or during viral pathogenesis. Some observations suggest there are complex relationships between DNA viral activity, transcriptional and post-transcriptional gene silencing mechanisms. - biotech-info.net by
- The biggest challenges in the field at the moment are understanding two things: how does DNA methylation participate in gene silencing (and that includes what molecules target the DNA methylation to these promoter regions), and why is the cancer cell doing this? - The Thomson Corporation by
- In 2005, Pikaard and his collaborators published research showing that the major function of Pol IV is to generate siRNAs, thereby singling out this RNA polymerase as a potential player in gene silencing. - ScienceDaily LLC by
Compare [close] - Italian
- Biology (-tech,-chem,micro-)
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- Il silenziamento genico è un meccanismo che permette di “spegnere” i geni localizzati in
specifiche regioni cromosomiche (anche piuttosto estese) attraverso la modificazione della
struttura della cromatina o la metilazione del DNA. Nel primo caso, la cromatina può
assumere una struttura più compatta denominata eterocromatina (tipica dei centromeri e dei
telomeri) che rende il DNA non accessibile dall’apparato trascrizionale. Research Network of Bioinformatics and C - by Mirra_
- Example sentence(s)
- E’ plausibile infatti che lesequenze pararetrovirali endo-gene rappresentino dei veri epropri “transgeni naturali” i cuiRNA ve rr e bbero individuatidalle cellule ospiti come invaso-ri, mettendo così in moto ilsistema di silenziamento genicodella pianta, a protezione dall’in-fezione di virus esogeni dellostesso tipo - Accademia dei Georgofili by Mirra_
- La metilazione del promotore determina un silenziamento genico e dunque la mancata espressione della proteina - Farmacie Comunali Riunite by Mirra_
- Nonostante l’antica origine, i viroidi sono estremamente attuali non solo per i danni economici che essi inducono in alcune coltivazioni, ma anche per i contributi alle conoscenze biologiche generali derivanti dagli studi su questi patogeni. A tale proposito, oltre ai ribozimi, vanno ricordate le scoperte della metilazione del DNA mediata da RNA e della RNA polimerasi RNA dipendente, entrambe coinvolte nel silenziamento genico. - CNR by Mirra_
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Compare [close] Compare [close] - Turkish
- Biology (-tech,-chem,micro-)
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- Birçok tıbbi makalede bu şekilde dilimize girmiştir. Google Documents - by Murat Uzum
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- Ortadoğu Teknik Üniversiteli (ODTÜ) araştırmacılar, tahılda rekoltenin düşmesine neden olan buğdayda sarı pas, arpada külleme hastalığında rol alan bir genin işlevini gen susturma yöntemiyle tanımlamayı başardı. - Genç Ziraat by Murat Uzum
- ABD'li ve Alman bilim adamları, insan vücudunun yapıtaşlarından RNA sayesinde 'gen susturma' adı verilen yöntemle hastalıklı genlerin 'kapatılabileceğini' açıkladı. - Gen Bilim by Murat Uzum
- RNA interferans, çift iplikçikli RNA'nın hücreye girdiğinde homoloğu olan mRNA'nın yıkılması ile sonuçlanan transkripsiyon sonrası gen susturma mekanizmasıdır - Pamukkale Üniversitesi SBE by Murat Uzum
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Compare [close] - Catalan
- Biology (-tech,-chem,micro-)
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- Procés durant el qual un gen no s'expressa. Termcat - by Marià Pitarque
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- D'altra banda, ARN petits, de tant sols uns 21-22 nucleòtids de llargada, també poden regular l'expressió de gens. Alguns d'aquests ARN actuen sobre regions del trànscrit madur d'un gen abans de la subseqüent síntesi de proteïna, aconseguint silenciar el gen. Mecanisme conegut com silenciament genètic postranscripcional o PTGS. - UPF by Marià Pitarque
- El treball dels científics de l’ICO Girona no acaba aquí. Mitjançant l’ús de fàrmacs experimentals i tècniques de silenciament genètic han demostrat que la inhibició de l’autofàgia fa que les cèl·lules resistents es tornin sensibles al trastuzumab de nou. - ICO by Marià Pitarque
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