English term
vitamin k-dependent plasma glycoprotein
This gene encodes a liver vitamin K-dependent glycoprotein that is synthesized in the liver and secreted into the plasma. The encoded protein plays a role in regulating blood coagulation by complexing with protein Z-dependent protease inhibitor to directly inhibit activated factor X at the phospholipid surface. (National Center for Biotechnology Info.)
Protein Z is a vitamin K-dependent glycoprotein isolated and characterized from human and bovine plasma. A cDNA coding for human protein Z has been obtained by the isolation of phage clones from a liver cDNA library and in vitro amplification of two other liver libraries. (Research Gate)
Four proteins active in blood coagulation have long been known to require vitamin K for their proper biosynthesis: factors II, VII, IX, and X. This paper describes the purification of a hitherto unrecognized vitamin K-dependent glycoprotein from bovine plasma. The biosynthesis of this protein is interfered with by the vitamin K antagonist Dicoumarol. (The JBC)
4 +3 | Vitamin-K-abhängiges Glykoprotein |
Isabella Hansmann, MSc, MA
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Proposed translations
Vitamin-K-abhängiges Glykoprotein
Protein C, ein Vitamin-K-abhängiges Glykoprotein, wird durch den Thrombin-Thrombomodulin-Komplex zu aktiviertem Protein C (APC) umgewandelt, welches in Gegenwart seines Cofaktors, Protein S, selektiv die Gerinnungsfaktoren Faktor VIII und Faktor V hemmt, wodurch das prokoagulatorische System reguliert wird. (Springer Link)
Protein Z ist ein Vitamin K-abhängiges Glykoprotein, das als Cofaktor für die Inaktivierung von FXa durch das Serpin "Protein-Z-abhängiger Proteinaseinhibitor (ZPI)" beschleunigt. (Lexikon der Mediz. Laboratoriumsdiag.)
Faktor VII (FVII) ist ein Vitamin-K-abhängiges Glykoprotein, das in der Leber synthetisiert und ins Blut abgegeben wird. (Medizinische Genetik)
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