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Sample translations submitted: 1
English to Italian: Farmaceutico General field: Medical Detailed field: Chemistry; Chem Sci/Eng
Source text - English Fluticasone propionate, the active component of FLONASE (fluticasone propionate) Nasal Spray, is a synthetic corticosteroid having the chemical name S-(fluoromethyl)6?,9-difluoro-11?-17-dihydroxy-16?-methyl-3-oxoandrosta-1,4-diene-17?-carbothioate, 17-propionate and the following chemical structure:
Fluticasone propionate is a white to off-white powder with a molecular weight of 500.6, and the empirical formula is C25H31F3O5S. It is practically insoluble in water, freely soluble in dimethyl sulfoxide and dimethylformamide, and slightly soluble in methanol and 95% ethanol.
FLONASE (fluticasone propionate) Nasal Spray, 50 mcg is an aqueous suspension of microfine fluticasone propionate for topical administration to the nasal mucosa by means of a metering, atomizing spray pump. FLONASE (fluticasone propionate) Nasal Spray also contains microcrystalline cellulose and carboxymethylcellulose sodium, dextrose, 0.02% w/w benzalkonium chloride, polysorbate 80, and 0.25% w/w phenylethyl alcohol, and has a pH between 5 and 7.
It is necessary to prime the pump before first use or after a period of non-use (1 week or more). After initial priming (6 actuations), each actuation delivers 50 mcg of fluticasone propionate in 100 mg of formulation through the nasal adapter. Each 16-g bottle of FLONASE (fluticasone propionate) Nasal Spray provides 120 metered sprays. After 120 metered sprays, the amount of fluticasone propionate delivered per actuation may not be consistent and the unit should be discarded.
Translation - Italian Il Fluticasone propionato, il principio attivo del FLONASE (fluticasone propionato) Spray Nasale, è un corticosteroide sintetico la cui denominazione chimica è: S-(fluorometil)6-alfa, 9-difluoro, 11beta-17-diidrossi-16-alfa-metil-3-ossoandrosta-1,4-dien-17-beta-carbossilico, 17-propionato e ha la seguente struttura chimica:
Il Fluticasone propionato è una polvere bianca o biancastra con una massa molecolare di 500,6 e la sua formula molecolare è C25H31F3O5S. E’ praticamente insolubile in acqua, liberamente solubile in dimetilsolfossido e dimetilformammide e poco solubile in metanolo e in etanolo 95%.
FLONASE (fluticasone propionato) Spray Nasale 50 microgrammi è una sospensione acquosa di fluticasone propionato micronizzato per somministrazione topica sulla mucosa nasale mediante uno spray nebulizzatore con pompetta dosatrice. Contiene inoltre: cellulosa microcristallina e sodio carbosibetilcellulosa, destrosio, benzalconio cloruro 2% p/p, polisorbato 80, alcol-feniletilico 0,25% p/p e ha un PH compreso tra 5 e 7.
Innescare la pompetta prima dell’utilizzo e dopo un periodo di inutilizzo (1 settimana o più). Dopo l’innesco iniziale (6 azionamenti) ciascuna erogazione rilascia 50 microgrammi di fluticasone propionato diluito in 100 mg di soluzione attraverso l’adattatore nasale. Un flacone di FLONASE (fluticasone propionato) assicura 120 somministrazioni spray. Raggiunte le 120 somministrazioni spray il dosaggio del principio attivo per spruzzo potrebbe non essere costante pertanto si consiglia di gettare il flacone.
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